this post was submitted on 14 Oct 2025
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[–] sp3ctr4l@lemmy.dbzer0.com 10 points 4 months ago* (last edited 4 months ago) (1 children)

Its more than a tautology, you are oversimplifying.

Or, well, as always with writings on or about science aimed at a general audience... the writers are oversimplifying, always read the paper.

https://www.nature.com/articles/s41586-025-09542-6

What they are describing is that those diagnosed early have a different behavioral psychological profile, different set of observed behaviors, than those diagnosed later.

They are saying that ASD has roughly two different sets of distinguishable behavioral profiles, and one of those sets is so obvious it tends to get diagnosed early, and another set is less obvious such that it tends to get diagnosed later.

While they seem hesitant to use the terminology of saying 'there may be two fairly distinct subtypes of autism', likely because they want to emphasize that more research needs to be done, they do not want to lead to people making rash and non nuanced conclusions... that basically is what they are saying, that there appear to be distinct genetic profiles that produce observably different 'kinds' of autism.

They ran a battery of statstical meta analysis on different genomes and behavioral profiles of Autists, and this chart I think summarizes it best:

(Those bars are 95% confidence intervals)

Two, fairly distinct behavioral/neurodevelopmental/phenotypical profiles, that also go along with two, fairly distinct underlying genomic profiles.

[–] mcv@lemmy.zip 4 points 4 months ago (1 children)

That is much clearer than the article puts it. Thank you.

[–] sp3ctr4l@lemmy.dbzer0.com 1 points 4 months ago

Thank you for appreciating the summary! =D