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Pretty sure this is how we ended up with Olestra; the oil substitute that gave people leaky anuses.
That's the problem with most substances with no caloric value, the body can't absorb it and tries to get rid of it by inducing the shits. Your colon is like: "Wtf is this dude eating mud?".
This is why those sugar-free gummy bears give people epic diarrhea, they are almost completely sugar replacements. The brain and nose/mouth love it, but the intestines can't do anything with it and want to get rid of it ASAP.
I'm not sure there is a way to fix this, which is kinda sad because I really want to lose weight, but also stress eat sweets.
Reverse chirality sugar may be a way forward, but nobody has figured out how to make it cheap in large quantities.
Obligatory...