this post was submitted on 06 Jun 2024
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No Stupid Questions

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I often take painkillers (acetaminophen aka paracetamol), but I've noticed that it's much more effective if I take them TOGETHER with my ADHD medication (ritalin aka methylphenidate) + my morning coffee. If I don't take them AT the same time, the painkiller is far less effective.

I do not exceed the maximum dosage of painkiller (1gram per intake, mornings), but alone this would barely suffice to kill my morning headache.

My hypothesis is that since the LIVER has to convert all three, I am effectively overdosing on either substance (painkiller or ADHD meds), and damaging my liver in the process.

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[โ€“] KittenBiscuits@lemm.ee 35 points 5 months ago (1 children)

Long time headache adventurer here.

You are basically making a homemade Excedrin (acetaminophen + aspirin + caffeine). Stimulants cause your body to metabolize the pain reliever more quickly.

As for if you're ruining your liver, I can't say, other than you should probably go see you doctor and ask for a blood panel/ liver function test. Even if your liver values are normal, you'll know for sure, and have a baseline to compare future tests against. Plus your doctor may have some thoughts on why you're having a headache everyday.

For me it turned out that while i had acceptable blood pressure, it was high "for me", and a beta blocker took care of the most frequent headaches. But we didn't figure that out until we had ruled out a whole bunch of other things.

It was a frustrating journey to be sure. I wish you luck in yours.

[โ€“] dysprosium@lemmy.dbzer0.com 2 points 5 months ago

Perhaps you're hitting the nail on the head. My blood pressure is apparently normal (at least during the day). But perhaps it is indeed too high for me. It feels plausible but idk what that is worth. I'm going to ask my doctor to test this idea. Not sure yet which med for lowering blood pressure is good. I thought that Beta blockers were specifically for headache patients. Perhaps this is why... Also, apparently ACE inhibitors and ARBs are also blood pressure lowering agents. Any experience with those...?