this post was submitted on 08 Aug 2025
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Yep, that's leptin resistance for you. Obesity is really a hormonal condition, and this is why GLP-1 inhibitors are so effective - they actually treat the hormonal condition and allow the recipient to manage their food intake without having their body hormonally work against them.
A layman's explanation (to be clear, I am the layman) of my best understanding of the subject:
Hunger is controlled by 2 hormones:
As fat cells accumulate, leptin levels also increase, but a person that has developed leptin resistance will not feel the appropriate amount of hunger suppression from the leptin, leading to chronic hunger unless large energy intake is sustained.
Does either of those cause/prevent actual starvation feelings, like headaches and fatigue? Do they influence your non-exercise activity thermogenesis? (ie, feeling like you need to sit while you wait for the bus instead of standing or pacing) Or is it just a vague munchiness?
I don't know the subject well enough to tell, unfortunately.