Yes. There’s black, grey, and then red and blue (which export in color but show up on the screen as different shades of grey). If I’m drawing a graph with different colors, I’ll typically use a standard black line and a thicker red or blue (grey) marker and they show up very differently.
If I need three colors, I’ll use a thin black pen line, a thicker blue (gray) pen line, and a thickest red (different gray) marker and I can generally differentiate them, even on the grayscale screen.
It also has different colors of highlighter (yellow, pink, and green) which are a little harder to differentiate but are each a little different