South Park

Kenny and his little sister. That episode where he got her the doll made me cry.

Stan and Kyle. But I do love Randy and Towelie. 🤣🤷‍♀️

Mr Slave and Lemmiwinks

Stan and Kyle for the friendship, Craig and Tweek for the relationship

Cartman and Butters is certainly the most entertaining for me.

Randy and tegridy

kenny and death

Scott and Diabetes

Kenny and d/eat/h

craig and tweek, kyle and stan, butters and kenny (they stayed in contact for a long while), cartman and kfc, randy and weed, etc

Unpopular opinion: Butters and Kenny in Going Native

https://www.deercowboy.com/soundboard/terrance-and-phillip

Santa and mr Hanky

The Dumb Prince and His Stupid Wife.

Chef and his chicks

Kyle and Cartman

Ike and his teacher

Big gay Al nd his farm

What about the girls?

Wendy and BeBe

Butters and professor chaos and inspector butters are my fav friendship. They all get along great. Great minds think a like and such

Nathan and Tardicaca Shark

Kenny and his little sister.

I’ll let y’all guess my favorite based on my name

Paris Hilton and Butters

I'd say, in a familial sense, Cartman and Liane's relationship is definitely the most interesting.

You're my super best friend too Kyle.

Dr. Mephesto and Kevin

either craig and tweek or stan and kyle :3

Butters and Dougie, their friendship is very wholesome and their villain duo is fun!

Towlie and randy as business partners is pretty dope

South Park made my friendship

Timmy and Gobbles

Jimmy and Timmy, from how they met to now it’s a great full circle of a relationship

Stan and Kyle!!

Cartman and Clyde Frog

Or the refreshing flavor of mint with a satisfying crunch

Cartman and his cheesy puff

Randy and Sharon. They have such "fun" together.

Kenny and Cartman

Cartman and Kyle.

Its just amazing what those 2 did to each other and still be friends and talk to each other daily like nothing happened

Cartman and butters

Stan and being sick

Randy and Crème fraîche