Technology

59575 readers

3545 users here now

This is a most excellent place for technology news and articles.

Our Rules

Follow the lemmy.world rules.
Only tech related content.
Be excellent to each another!
Mod approved content bots can post up to 10 articles per day.
Threads asking for personal tech support may be deleted.
Politics threads may be removed.
No memes allowed as posts, OK to post as comments.
Only approved bots from the list below, to ask if your bot can be added please contact us.
Check for duplicates before posting, duplicates may be removed

Approved Bots

founded 1 year ago

MODERATORS

1124

Moderna’s mRNA cancer vaccine works even better than thought (www.freethink.com)

submitted 10 months ago by sanqueue@lemmy.world to c/technology@lemmy.world

204 comments fedilink hide all child comments

you are viewing a single comment's thread
view the rest of the comments

[–] Natanael@slrpnk.net 7 points 10 months ago (1 children)

There's still ways but not trivial. You have to do multifactor analysis, but it's gonna have a ton of noise unless you have a large sample of different people with recurring "neoantigens". It's similar to how drug side effects are tracked for people who take multiple medicines, you compare against populations which share different combinations of the same factors.

[–] wewbull@feddit.uk 2 points 10 months ago* (last edited 10 months ago)

Multifactor analysis still requires an underlying commonality. People taking multiple drugs are all still taking the drug being trialed. You're removing the confounding factors. If every treatment is a unique cancer protein there is no common factor. The treatment is the confounding factor.

To put it another way. A safety trial has to prove that any protein administered is safe.

Edit: just realised you're probably talking about efficacy trials, whereas I'm more concerned with safety.