I've been playing Enderal (a Skyrim total conversion) with some added QoL mods on my Deck

Got MO2 working with Enderal on wine by using this. The script (and MO2 itself) is a bit janky but it does function. The only thing I couldn't get working was the nexus mods URL integration thingie, had to download mod packages and add them manually.

The game itself runs like a charm on the Deck (after setting up a control profile anyway).

But there is the catch that being a Total Conversion mod that is available on Steam... Enderal itself points steam to SKSE on launch. Don't know how it'd work if your starting point is Vanilla Skyrim.