this post was submitted on 09 Sep 2024
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Mildly Infuriating

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I don't see how this is legal, but people on Tik Tok peddling miracle "medicine" are becoming more common every day. No FDA approval, no research. Just their marketing hype and false promises. This one, lady is showing some sort of probiotic and claiming it can help people suffering from severe acid reflux and gastrointestinal reflux disease or GERD, replacing medicine that has been tested for decades.

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[–] SnotFlickerman@lemmy.blahaj.zone 1 points 2 months ago* (last edited 2 months ago)

So the CBD thing really bugs me, in particular.

One of my medications has one of those warnings about how you can't have grapefruit while taking this medication. That's because grapefruit is metabolized on a certain enzyme pathway that gets interrupted. That enzyme pathway is CYP3A4.

You know what else takes that enzyme pathway? Fucking CBD. It also blocks the enzyme pathway, making any drugs administered less effective because they can't bind to where they need to because the CBD molecule is already there, taking up space.

So like, for me, these are life saving medications so fucking around with this is really stupid but literally no doctor told me this. I accidentally figured this out while doing research on CBD. It seems like its becoming more publicized now, but the bottom line is this:

If you have medication that warns you that you should not eat grapefruit with this medication (about 60% of medications, I believe), that medication needs the same warning about CBD.

https://www.pharmacytimes.com/view/cannabidiol-presents-conundrums

Upon further evaluation, it was shown that CYP3A4 and CYP2C19 are the 2 major enzymes responsible for the metabolism of CBD; they are also responsible for the metabolism of many different drugs.