Science

12955 readers

10 users here now

Studies, research findings, and interesting tidbits from the ever-expanding scientific world.

Subcommunities on Beehaw:

Space

Be sure to also check out these other Fediverse science communities:

This community's icon was made by Aaron Schneider, under the CC-BY-NC-SA 4.0 license.

founded 2 years ago

MODERATORS

Gaywallet@beehaw.org

alyaza@beehaw.org

remington@beehaw.org

126

Brain's Weight Switch Found: May Let Us Eat What We Want, Finally (neurosciencenews.com)

submitted 1 year ago by will_a113@lemmy.ml to c/science@beehaw.org

57 comments fedilink hide all child comments

A new discovery reveals that astrocytes, star-shaped cells in the brain, play a key role in regulating fat metabolism and obesity. These cells act on a cluster of neurons, known as the GABRA5 cluster, effectively acting as a “switch” for weight regulation.

The MAO-B enzyme in these astrocytes was identified as a target for obesity treatment, influencing GABA secretion and thus weight regulation.

KDS2010, a selective and reversible MAO-B inhibitor, successfully led to weight loss in obese mice without impacting their food intake, even while consuming a high-fat diet, and is now in Phase 1 clinical trials.

you are viewing a single comment's thread
view the rest of the comments

[–] naqahdah@my.lserver.dev 27 points 1 year ago

Every time I see one of these weight loss miracles, I wait for the other shoe to drop... and it usually does.

As I have learned the hard way in my own life, the weight loss miracle is setting a calorie limit and strictly adhering to it (barring medical complications... which, let's face it, most of the people who say those cause issues with them losing weight probably don't have them).

The weight loss miracle I'm waiting on is the pill that rewires your brain to change your relationship with food because, man... that's the hard part. Having to constantly fight my own brain - no, you aren't hungry, you're bored; yes, you actually are satisfied eating a happy meal for 550 cals, you actually do not need a 2 cheeseburger meal large size at 1200 cals, and so on - that's the struggle for me. I'm down from 270 to 240 so far, but I'd be lying if I said it wasn't still a constant fight, which is probably what makes relapsing after taking all these drugs such a common thing.