this post was submitted on 04 Sep 2023
126 points (100.0% liked)

Science

12955 readers
10 users here now

Studies, research findings, and interesting tidbits from the ever-expanding scientific world.

Subcommunities on Beehaw:

Be sure to also check out these other Fediverse science communities:

This community's icon was made by Aaron Schneider, under the CC-BY-NC-SA 4.0 license.

founded 2 years ago
MODERATORS
Gaywallet@beehaw.org
alyaza@beehaw.org
remington@beehaw.org
126
Brain's Weight Switch Found: May Let Us Eat What We Want, Finally (neurosciencenews.com)
submitted 1 year ago by will_a113@lemmy.ml to c/science@beehaw.org
57 comments fedilink hide all child comments
 

A new discovery reveals that astrocytes, star-shaped cells in the brain, play a key role in regulating fat metabolism and obesity. These cells act on a cluster of neurons, known as the GABRA5 cluster, effectively acting as a “switch” for weight regulation.

The MAO-B enzyme in these astrocytes was identified as a target for obesity treatment, influencing GABA secretion and thus weight regulation.

KDS2010, a selective and reversible MAO-B inhibitor, successfully led to weight loss in obese mice without impacting their food intake, even while consuming a high-fat diet, and is now in Phase 1 clinical trials.

you are viewing a single comment's thread
view the rest of the comments
[–] meteorswarm@beehaw.org 4 points 1 year ago

https://slimemoldtimemold.com/2021/07/11/a-chemical-hunger-part-ii-current-theories-of-obesity-are-inadequate/ is a good analysis of why calories in calories out is both true and not a good model for how weight gain/loss works in people.