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Millions in west do not know they have aggressive fatty liver disease, study says (www.theguardian.com)

submitted 1 day ago by MicroWave@lemmy.world to c/health@lemmy.world

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Research finds more than 15m in US, UK, Germany and France with MASH have not been diagnosed

More than 15 million people in the US, UK, Germany and France do not know they have the most aggressive form of fatty liver disease, according to research.

Metabolic dysfunction-associated steatotic liver disease (MASLD) – the formal name for non-alcoholic fatty liver disease – occurs in people who drink no or minimal amounts of alcohol whose liver contains more than 5% fat.

About two-thirds of patients with type 2 diabetes are thought to have the condition, which is also associated with obesity, heart and circulatory disease.

Approximately 5% of adults globally have the most aggressive form of MASLD. Metabolic dysfunction-associated steatohepatitis (MASH) causes fibrosis (scarring) and can lead to cirrhosis and is linked to greater risk of cardiovascular disease, chronic kidney disease and liver cancer.

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[–] jet@hackertalks.com 6 points 1 day ago (7 children)

The most common cause of NAFLD is persistent fructose consumption. I.e. sugar

The most effective way to treat/reverse it is to eat a carbohydrate free diet

[–] Aninie@feddit.online 3 points 1 day ago (1 children)

Why does it need to be carbohydrate free diet? Would not just excluding fructose and carbohydrates containing fructose be equally effective?

[–] jet@hackertalks.com 5 points 1 day ago* (last edited 1 day ago)

It would be effective but not as effective.

Once there's fat in the wrong places, ectopic fat, the body does not like fat inside of organs. You want the body to mobilize that fat as soon as possible. So you remove all carbohydrates to help the body stay in a fat burning metabolism. That way the body will remove the organ fat as quickly as possible.

If you're still eating a carbohydrate-rich diet, but no fructose, you're not continuing the most significant risk factor that's true, but the body has elevated insulin when you eat carbohydrates, and cannot mobilize fat until all of that insulin is back to normal. For most people they're eating three big meals a day and a bunch of snacks, which means they're insulin is always up. Which means it's very hard to remove that fat from the organs

So, removing all the carbohydrates, gets the insulin back to normal, allowing the body to mobilize fat, and the The body does prioritize removing ectopic fat from the organs when it can

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