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Unnatural evolutionary processes of SARS-CoV-2 variants and possibility of deliberate natural selection (zenodo.org)

submitted 1 year ago by fluid_neutral@lemmy.today to c/science@kbin.social

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As a result, we concluded that the formation of a part of Omicron isolates BA.1, BA.1.1, and BA.2 was not the product of genome evolution, as is commonly observed in nature, such as the accumulation of mutations and homologous recombinations. Furthermore, the study of 35 recombinant isolates of Omicron variants BA.1 and BA.2 confirmed that Omicron variants were already present in 2020. The analysis showed that Omicron variants were formed by an entirely new mechanism that cannot be explained by previous biology, and knowing how the SARS-CoV-2 variants were formed prompts a reconsideration of the SARS-CoV-2 pandemic

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[–] ScarletIndy@kbin.social 1 points 1 year ago* (last edited 1 year ago)

This is missing the biggest piece: phylogenetic analysis. They aligned a selected group of mutations and then eyeballed the alignments and then speculated.

Here’s what the methods section for this paper should look like in order to make the theoretical leap.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969601/

A reasonable phylogenetic tree is here: https://nextstrain.org/ncov/gisaid/global/6m