Quick edit/ update.
I've looked deeper into the topic and found some more information.
It's pretty much non-toxic to bees and mammals. It works by making pests, that ate affected leaves, stop eating and weakening them because of that. It doesn't poison them. They just starve.
It seems to degrade very fast by all influences, even water alone and is only active for a few days.
Source (very recommended to read!): https://npic.orst.edu/factsheets/neemgen.html