I play video games while exercising. Switch controllers in either hand while walking on a treadmill works really well.
I haven't been depressed in a while, but I found extreme cardio to be a really good mood lifter, especially when playing a fun game.
I would also recommend avoiding triggers. News is mental poison. I have no idea what is happening in the world and I am substantially happier as a result.
I used to invert x and y. But at some point I realized that all modern games seem to support non-inverted, but only some support inverted on both axes, so I just learned to play non-inverted to save myself the hassle.