Look I love South Park, I've been watching it for decades, but there's one thing that basically every South Park subject has in common so often that it's kind of boringly predictable: Matt and Trey are almost always mocking everyone on every side of every issue for getting too invested in it.
A lot of the time, they're right to do so, because everyone's acting silly. Sometimes I think they are making a mistake to choose the centrist perspective, but that's a function of my beliefs. I do think some things are worth getting fired up about. But at the end of the day they're a comedy show and the goal is to laugh at everything.
They're never going to be on someone's side 100%. They've established that.
I think it was a joke about how multiverse movies and shows, despite supposedly being about the wild and infinite variation that would be possible across a spectrum of infinite alternate universes, tend to wind up showing us a bunch of extremely similar versions of the same stuff. All that's changing about Randy is which American football jersey he's wearing, an almost meaningless difference, but everyone behaves as though the change is profound and disturbing.