My wife is incredibly resistant to Novocaine. She's gotta arrive at the dentist just after throwing back a Klonopin and even then her most recent bit of dental work required a total of SIX VIALS on increasingly stronger Novocaine.
But then she'll get general anesthesia and not even get through half the pediatric dose before she's knocked out way longer than recovery would expect despite being almost 5'11" and weighing like 190lbs. Like when she was ordering her wedding dress the people making it thought she was trolling because there's no way her shoulders were as wide as she said they were. Iirc she had to provide a picture of her taking the measurements so they could see that she wasn't trolling or measuring wrong.
She's also a super lightweight with alcohol so it's like if it crosses the blood brain barrier she's fucking done and if not she's a walking tank.
My wife is the same way. Not ginger that we can tell but the pain meds and anxiety are pretty similar. She's gotta throw back a full Klonopin to not have ridiculous anxiety in the dentist and still needs multiple vials of numbing to do anything. Took her forever to find a dentist that actually listened to her about the Novocaine not working well and to actually get proper numbed before dental work.