This is especially true if a simulated universe is indistinguishable from base reality - so perfect in all its aspects that it is identical.
You can also get into the fact that we do not and can not objectively experience reality, simulated or not. Our experience and perception is based on the senses we have, which are inaccurate, and the brain that interprets the inputs, which makes shit up and is wrong all the time. Yes, we can use tools and measurements to enhance our perception and make it more accurate as far as understanding is concerned, but we actually each live in a universe manufactured by our own mind.
ACAB ... including Sting.