UraniumBlazer

I love this artist so much! Please do check her out.

TLDR: Google's DeepMind has developed a new open sourced AI system called AlphaProteo, which can design novel proteins that bind to target molecules. This technology has the potential to accelerate progress in various fields, including drug development, disease understanding, and diagnosis.

AlphaProteo was trained on vast amounts of protein data and has learned the intricate ways molecules bind to each other. It can generate candidate proteins that bind to target molecules at specific locations, and its designs have been validated through experiments.

The system has shown promising results, achieving higher experimental success rates and better binding affinities than existing methods. It has also been able to design successful protein binders for challenging targets, such as VEGF-A, which is associated with cancer and complications from diabetes.

However, the system is not perfect and has limitations, such as being unable to design successful binders against certain targets. To address these limitations, DeepMind is working to improve and expand AlphaProteo's capabilities.

The development of AlphaProteo raises important questions about responsible development and biosecurity. DeepMind is working with external experts to develop best practices and is committed to sharing its work in a phased approach.

Overall, AlphaProteo has the potential to revolutionize protein design and accelerate progress in various fields, but it requires careful consideration of its limitations and potential risks.

Hey everyone!

So I'm finally moving to Canada very soon (yayy). I'm moving to Calgary specifically. I asked this question in the Calgary community too, but I'll ask it here too for a Canada wide answer.

Are there any good cooperatives that I can support and purchase from? Sayyy large home furniture coops or phone co-operatives and so on... Are there any good news cooperatives? Maybe some nice clothing cooperatives? I know that credit unions are more province specific, but still... Any good credit unions that have a good Canada wide presence? Maybe little artisan shops in say some small town in Ontario that make good stuff n ship it across Canada?

Any name drops would be appreciated!

PS: I've heard about Calgary Coop, so yeah... Anything more than this?

Neural networks have become increasingly impressive in recent years, but there's a big catch: we don't really know what they are doing. We give them data and ways to get feedback, and somehow, they learn all kinds of tasks. It would be really useful, especially for safety purposes, to understand what they have learned and how they work after they've been trained. The ultimate goal is not only to understand in broad strokes what they're doing but to precisely reverse engineer the algorithms encoded in their parameters. This is the ambitious goal of mechanistic interpretability. As an introduction to this field, we show how researchers have been able to partly reverse-engineer how InceptionV1, a convolutional neural network, recognizes images.

Most states rely on paper bureaucracy to ensure that the state can function and provide services. Paper bureaucracy has been part and parcel of how we maintain states and corporations since the Chinese invented the first paper bureaucracy systems of management 3000 years ago. But as you all probably know, bureaucracy kinda sucks. It costs a lot to maintain, and in the worst cases bureaucracy can turn a state into a labyrinthian monstrosity that can be near to impossible to navigate.

Estonia is a Baltic country that in recent years has been embarking on reform programs that are intended to change this. Estonia is a “Paperless state” meaning a state that has effectively removed all paper from it’s bureaucracy and replaced it with a digital state structure. In this short video I would like to introduce you to the digital state and argue for it.

Edit: To those downvoting, could please comment the reason as to why you are downvoting? The comments that are there right now do not explain the reason for the downvotes. I am genuinely curious as to what the thinking behind disliking the post is.

Imagine you are a trans woman in the 15th century. You lack the tech to grow boobs. You lack the tech to make ur dick into a vagina. However, the want still exists and is very real.

Now imagine the year is 2124. You are 55 years old. The tech to look exactly like you looked when you were sayyy 12 exists. You want to look like that. I would say that looking like that is your right. It's your body after all.

However, you are still 55 years old. You just LOOK like a child. But you possess the ability to consent. Is having sex with such people moral? (I would say it is).

This however introduces problems. How do you differentiate between actual children and people who physically look like children? Would this be a political issue then? Would adults who want to have sex with adults (but those who look like kids) be discriminated against? Would there be movements for this?

I really really don't understand how people are either so tiny brained or so fkin inconsiderate. Probably this is the wrong community to post this, as my infuriation levels are far from mild.

Like... you look up a tutorial on a specific thing. You see a list of videos describing the very thing that you want in perfect English. You open the video to see that it is in a completely different language (usually Hindi). You then feel like personally going on a mission to assassinate that video creator. /s

Like come on... I understand that English alphabets are more readable to people who speak languages other than English. FINE. I GET IT. But would it be too much to ask to at least put the name of the fkin language that your video is actually in, in the title?

Like... it would so much better for a video title to be "(Hindi) Ranked Retrieval model explained" instead of "Ranked Retrieval model explained" and it turning out to be in Hindi. Like... do these people not think? Or do they not have a brain? Or do they just not care?

I scoured through SO MANY VIDEOS and all of them have this nonsense going on. Like come on....