There's other options like wine-staging and wine-devel for newer programs, and also there's paid options like CrossOver which can even be simpler to use than Wine.
If you want the latest Microsoft and Adobe software, you're likely going to be out of luck, but, if you want the latest Microsoft software you'd probably stay on Windows anyway.
Well I mean that's kind of what Lemmy is like since it's far more niche than something like reddit, but AI crawlers will find it anyway.