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The end of Windows 10 is approaching, so it's time to consider Linux and LibreOffice
(blog.documentfoundation.org)
This is a most excellent place for technology news and articles.
There may be a few more, but these are the big ones. JACK, at the moment, just isn't a replacement for Voicemeeter and while there are some DAWs for Linux, they're not FL and I don't know if they're compatible with Guitar Rig. I've used OpenShot for video as well, and while it's not terrible it isn't really comparable.
I'm sure that Linux is a good fit for many users. Personally, as an operating system alone if it weren't for these issues, I'd prefer it. I'd love to be able to do what I need to do and also have a plasma, it's much nicer. But at the moment it isn't a real option without sacrificing things that I actually need. I also really can't be dealing with suddenly needing to sort out how to make a finicky program work at the drop of a hat when I'm in the middle of working on a project.
I've been dabbling with Linux since the early 00s. I like it and I wish it were a substitute for Windows for my use case, but it isn't. No amount of people being rude and obtuse in threads will change that. Time might, but it hasn't yet.
Does it have separate audio channels and input/output controls with volume sliders and hotkeys? That would still leave a few other issues, but progress is progress and I do like to keep myself aware of the options so that I'll know when it finally ticks all the boxes.
I use pipewire with Ardour and Neural DSP VSTs (over wine) with zero issues on EndeavourOS. I really hadn't expected that. Now, I generally just use this stuff to not have to buy many physical pedals so I rarely do recording, but that has worked as well.
You seem to be way more advanced than me in that regard, so I can't say if it would work for you, but it was so much easier and better than when I tried the same thing years ago. I'd suspect that GuitarRig works as well, though I haven't tried. I may just do so this weekend, but can't promise.
I have GuitarPro running with wine as well.