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I've seen studies claiming that toilet seats are among the cleanest spots in a public restroom, and that slamming your bare ass cheeks down on those things is perfectly safe.
I also work in an operating room, where we routinely chop condyloma off of people's ass cheeks... albeit less commonly the cheeks than the hole, but enough times to showcase the fact that the cheeks are prone to spreading and contracting contact dependent pathogens.
Those studies are bullshit - always build that toilet-paper-bird's-nest on the public toilet seat.
Edit - also if you get a skin tag that seems bigger than a normal skin tag, it's probably not a skin tag. Get that shit looked at before it's the size of a fucking golf ball. You'll save yourself a lot of time, pain, money, and worry.
I even do it at home (just a couple squares on each side) for comfort