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The "buzz" or high is just the body's response to an abnormally activated hormonal or neurological system. But dependent on which system for the affect. Maybe a good feel system is extra activated, maybe a bad feel system is suppressed, or some other path.
Alcohol artificially activates your gaba system(calms or excites lots of processes which gives the alcohol buzz/relaxation) which causes it to dysregulate as it adjusts to the presence of alcohol over months and years of regular use. Withdrawals are that you feel depressed and anxious (your brain cannot chill), your judgment becomes impaired (as much as if you were drinking) and you learn alcohol is a great cure for the experience.
Other drugs have similar mechanics on dopamine, or seratonin, or other hormones. And the highs along with hangovers and withdrawals are correspondingly different.
The heightened presence over time dysregulates the body's affected system. Then short term sobriety leads to drug seeking behavior because the body learned that it's easier and less painful to take the substance than to wait and doing nothing while suffering and letting the brain learn to restore a baseline.
Do drugs sparingly, and if there's one you struggle to do sparingly, don't do it at all.
Lots of edits sry