Oh absolutely. I've already run it for years with a mixed hodgepodge of zigbee Z-Wave and Wi-Fi devices. The problem is that many still phone home to somewhere. I definitely want to get everything down to matter and threads on my local ha as much as possible.
Was looking at good options the other day for a thread border router. My father was an ESP based option. Though not the ubiquitous cheat esp32s
To them the facts never mattered. Just their feelings. So it's plenty in script for them.