Jarlsburg

I went to a John Kerry Rally in 2004. I got there about 30 minutes late and for whatever reason was ushered up to the front corral of people. Inexplicably, Bon Jovi takes the stage and shouts, "You what George Bush's financial policy is? Bad Medicine!" and launches into the song 'Bad Medicine'. I started laughing my ass off because it was corny as shit and Bon Jovi and I made eye contact for a brief second.

YMMV

This adds a whole new dimension to the lore.

One day a coworker of mine was walking into our huge office building and thought he saw a mitten on the ground of the lobby. When he picked it up it was actually a pair of lacy women's underwear. Ostensibly it fell out of someone's gym bag or got caught in their pant leg in the laundry and dislodged there. He drops it immediately and comes into the office. He doesn't mention this to anyone.

Two hours later the main receptionist comes in with the underwear in front of our whole group and says she saw him drop these this morning and she wants to return them. He's denying the whole thing and at this point none of us have the previous context and all locked in to the conversation and silent laughing. She says, "We just want to give these back in case they have sentimental value!" and the the whole group is dying laughing now. He eventually convinces her he isn't interested in a stranger's underwear (which she bare handing) to which she says she'll keep them in case he changes his mind (???).

It's been 5 years and it gets brought up nearly daily

I recently found out about the Zelda: Link to the Past randomizer community. Essentially there is a method to modify the original game to randomize the item locations and other aspects of the game while ensuring the game can be completed. Each game has a seed so you can look it up if you get to stuck. I played through it once and it was a really interesting challenge since I didn't get the bow until 60% of the way through the game.

I have never seen Discovery and SNW is very enjoyable. I am sure I am missing context, but I don't think it is significant enough to make Discovery mandatory.

hear ye

I played Like a Dragon with no background and it was a great experience. Really wacky in a satisfying way. Only grievance is there is ~10 hours of cut scenes to beat the game.

I commented this elsewhere, but to answer your question,

Zolgemsma is a modified version of adeno associated virus and has to be grown under specific conditions. It costs $500k-$1m per production. It's also a one time injection that functionally cures the person of the disease. There are a couple other options but for comparison, the other therapeutic is Spinraza which is an intermittent intrathecal infusion which is $805,000 for the first year of therapy and $380,000 per year thereafter for the rest of your life.

SMA type I also is 100% fatal by year 2-3 and the baby dies without being able to even lift their head. It's a terrible prognosis.

To be clear, I think we should bear the actual costs of research, development, and manufacture as a society and not profiteer off the sick, but there are some contributory reasons for the price.

Zolgemsma is a modified version of adeno associated virus and has to be grown under specific conditions. It costs $500k-$1m per production.. It's also a one time injection that functionally cures the person of the disease. There are a couple other options but for comparison, the other therapeutic is Spinraza which is an intermittent intrathecal infusion which is $805,000 for the first year of therapy and $380,000 per year thereafter for the rest of your life.

To be clear, I think we should bear the actual costs of research, development, and manufacture as a society and not profiteer off the sick, but there are some contributory reasons for the price.

Zolgemsma is a modified version of adeno associated virus and has to be grown under specific conditions. It costs $500k-$1m per production.

No one has given you an actual reply just assuming that the manufacturing costs for the drug are low. Zolgemsma is a modified version of adeno associated virus and has to be grown under specific conditions. It costs $500k-$1m per production.

Nethack is like the Jumanji of games. You finish it by introducing someone else to it.