For what it's worth, I use power profile daemon (PPD) on my AMD Framework 13, but also setup the systemd service for powertop's auto-tune, which is less invasive than TLP and can coexist with PPD (usually).
I've been running this way for a few days with no unexpected behavior, and the difference between PPD powersave and PPD powersave + powertop --auto-tune seems to be about ~1W at idle (i.e. I see a ~4.5 watt idle instead of a ~5.4 watt idle).
I'm not running Debian, but powertop is in Debian's repos so it may be worth a try. Powertop can also be used as a purely diagnostic tool to show you the estimated power draw in real time (after calibration), so you can see immediately if tweaks make a difference.
Generally the larger disks have similar failure rates to smaller onces, which means that, if you're running a storage array, increasing the number of drives actually increases your chances of experiencing a failure, even assuming the best case that drive failures are statistically independent events, which they are not.
Larger drives also make keeping full backups much easier (i.e. entire backup fits on a single disk, which makes it easier to make and store).