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I know it's for scientific purpose and all, and they signed off on it, but what a bum fucking deal to get a placebo in that stage 4 group.
A lot of times they don't do placebo once the trial gets to that stage. My dad with cancer was a treatment guinea pig & one of the study stipulations was that they wouldn't get placebo. Too cruel to get their hopes up. ETA: I know this one states it had placebo group. And I understand the reason for it, obviously. Just saying my dad's experience was they promised no placebo group bc it was so late stage in testing.
It could've gone the other way with worse outcomes for the medicine group.
In that case, you might want to be in the placebo group.
Either way it's a gamble
I've seen news of other experiments like this where once the treatment was so obviously working they flipped the placebo group over to the treatment as well out of compassionate grounds, but perhaps in this case the treatment is so expensive right now that they simply didn't have the resources to do that. So perhaps they went "our grant allows us to produce at most X number of doses of the real treatment for this, so let's take on 2X patients for it," and ended up saving the largest number of people they could have.
In later trials, drugs aren't compared against placebo, but a standard therapy regimen.