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Depends what you mean by Infection, the main thing you want to protect yourself against is Ransomware vulnerabilities which is the biggest issue i see with Synology/QNAP/DROBO etc... I make good $ with clients that get infected. My recommendation.. get yourself a NAS such as a Synology, and backup to the cloud, there are many cloud providers which support NAS backups, Synology has their own service and its very affordable. Onedrive is also a very good alternative as you mentioned, however the limitation is 1TB, remember the "infection" will not be transferred to Onedrive, assuming you're concerned about viruses, just get yourself a good AV such as Sophos or Bitdefender and update your OS every month. From what i read, you're safer backing up to a proper cloud provider than storing another NAS at your parent's house... a cloud backup can be encrypted so that no one can access those files... Encryption + MFA and you're relatively safe.