In my experience absolutely but amp/dac upgrades on my existing gear would be a 2x cost of dac and amp.
I currently use a $4000 r2r dac, and ive identified and tried my amp with two absolutely better dacs that i want to upgrade to but cant afford yet. The Weiss 502 dac or the Lampizator big 7.
My amp currently is $6000 and the Viva Egoista 845(12k and above) I was able to demo at a meet trounces it handily.
Not in the path of upgrading for now ive kind of settled but curiosity can hurt wallets thats for sure.
Alternatively a good audio buddy of mine into Stax has been eyeing on upgrading from his headamp blue hawaii to a Custom T2 or Grand Cayman and is looking to sacrifice a lot in order to do so.