Basic answer - No
Even with full frame, you are still better off with using flash if you want enough light/low ISO for your pictures. Maybe if there was a very well light room with all the lights on, you could get away with it.
Even when I read about portrait photography for kids by professional photographers using low light photography technics, they placed their subjects by the window so they had enough light. They didn't take pictures in the middle of the room with low light.
I converted from APC-S to full frame (Nikon Z6) and I found for indoor use with people, flash is what I needed. Just too much movement and not enough light to capture spontaneous pictures.
I have yet to see a professional photographer at a wedding not use a flash on their camera and they have nice rigs for low light.