You need to take the time to regulate. If you don't then it just ends up in a meltdown at best, and a total shutdown at worst.
And I'm sure everyone would rather you just swerved a social event that deal with that. I know for me, at least, I'm utterly done mentally and emotionally for a couple of days after a shutdown.
I will hopefully assume your wife knows that you're autistic and your needs. Just tell her that you've gone none-stop for two weeks and that you're at critical point for regulation. If you can, might be worth taking sick leave from work.