It appears that every action is a reaction (or to use the more customary terminology, every action is an effect of some number of causes, and is in turn a cause for some number of effects).
However, it must either be the case that there was a first action, which would necessarily be an uncaused effect, or that time is either a loop or is infinite in extent, such that there is no beginning and thus no need for an uncaused effect.
And none of those possibilities is really intellectually satisfying, so it's an open question (which doesn't stop people from insisting on the nominal truth of one or another of them).