You usually cant go wrong always picking the original resolution. Its the only version that wasn't resized.
Science Memes
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Neither of the buttons says "original resolution".
That's fair but for me full-size = original-size. I assumed it was an existing synonym.
I couldnt think of an example where the full size is not equal to the original size of an image.
Full size as it would be printed on a physical page vs large size as it's in the database, maybe
Same.
It wasn't, the full-size is usually smaller, but I always forget to ignore it.
The meme is looking for the larger image, for some reason. Bot logic I guess.
When you read more papers from that publisher, you'll get it.
Unless 285kb is too much already
Amateurs...

Bottom white
Get an adblocker.
I bet it's the barely visible one at the bottom.
The one that's left over when you activate the adblocker.
I was having this issue on an Indonesian website yesterday, it was this memes equivalent of the purple button, no internet literacy could have prepared me for that madness.
center red button or the orange button at the bottom.
It’s full size, no?
Full size = original, so anything else would be a resize of it.
Or maybe I’m missing context/reference
Here's the one I made screenshots of for the meme: https://www.sciencedirect.com/science/article/abs/pii/S0048969725022776?via=ihub
In image compression, you can only ever lose information, you can never gain any. Hence, if you want the highest available quality and don't care at all about space savings, you should select the original.
but the original is not available for download on the publisher's site.
My impression was that full size was equivalent to original here, that may have been a misunderstanding on my part.
No, that's the point of the meme. They're using confusing buttons.
Example: https://www.sciencedirect.com/science/article/abs/pii/S0048969725022776?via=ihub
https://www.sciencedirect.com/science/article/pii/S2665972726000978?via=ihub