There are many benefits for experiencing altered states of awareness, including opportunities for pain management, reduced fears of death and dying, and increased access to personal insight and development.

And also, choices in every area of our lives can have trade-offs and risks. It is important for all of us to have an accurate understanding of the advantages and potential disadvantages of any choices that we might make.

One specific danger that people should be aware of, especially anyone in their teenage years or early twenties who has a family history of schizophrenia, is that cannabis use can activate an underlying condition if a person has a predisposition for this.

The exact functions of this connection, called the Dopamine Theory, are still not fully understood, but enough evidence has been observed that people who may be vulnerable in this way should understand an accurate picture of the risk.

Here are a few articles on the subject.

https://en.wikipedia.org/wiki/Dopamine_hypothesis_of_schizophrenia

https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2832297

https://pmc.ncbi.nlm.nih.gov/articles/PMC7442038/

https://crownviewpsych.com/blog/cannabis-psychosis-dopamine/

https://psychscenehub.com/psychinsights/the-dopamine-hypothesis-of-schizophrenia/

Psychonauts have talked about the importance of set and setting for ages. He's talking about the same stuff with different vocabulary. These drugs can have real effects, it's important to be mindful of the risks.

One where the cops don't come busting through the door because you're freaking out and the neighbor called. Ideally with a trip sitter in a place you feel comfortable, i personally would suggest somewhere natural and far away from other people.

There are contraindications.