Oh hell yea. It’s a big house rules game. In the drug and alcohol program I worked with I got to go to all sorts of detention centers for minors.
They had so many fun rules. One group called it Spicy Uno and had rules for regular cards too.
A 7 is played and no one can talk until another 7 is played, each word or sound is draw a card regardless of active turn.
A 6 was waterfall, last person to raise their arms over their head draws a card.
If the reverse card matches the color, anything can be reversed. Even on a multicolor draw card, whoever played the multicolor has to pick one of the colors.
If you have the twin(same color and symbol) of a card just played you can “jump in” to the turn rotation and continue in the same direction as if it was the “jumpers” original turn. This one was my favorite I think.
I use them to hide how scared I am.