It would be great if the medical system had a way to see trends in data, if heading toward metabolic issues, chronic inflammation, before diabetes, types 2 and 3! Ahh, but fasting insulin and crp tests are cheap, don't make much money for the system to prevent issues early, with lifestyle changes and not need treatments!
"Insulin resistance develops 10–20 years before fasting glucose or HbA1c cross into the prediabetic range. During that window, the pancreas compensates by pumping out progressively more insulin to keep glucose "normal", which is what those markers capture.
HOMA-IR is the primary equation used to assess insulin resistance, calculated as (Fasting Insulin × Fasting Glucose) / 405, with values >2.0 indicate significant resistance and >2.9 metabolic syndrome. Triglyceride/HDL ratio is another marker for insulin resistance, with a target of <1.0 and high-risk values exceeding 3.0.
Fasting insulin levels are independently associated with high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation; higher fasting insulin predicts elevated CRP.
A nasty mechanism, the enzyme IDE (insulin-degrading enzyme) clears both insulin and Aβ. When hyperinsulinemia (from gut-driven peripheral IR) floods the system, IDE gets occupied by excess insulin and can't clear Aβ as efficiently, plaques accumulate "*
- confirm for accuracy