this post was submitted on 08 May 2025
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Moderna's combo Covid and flu mRNA shot outperforms current vaccines in large trial (www.nbcnews.com)
submitted 2 months ago* (last edited 2 months ago) by MicroWave@lemmy.world to c/health@lemmy.world
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A combination shot would make it easier for people to get vaccinated against Covid and the flu at the same time.

Moderna’s combined Covid and flu shot outperformed the existing standalone vaccines for both viruses, according to the results of a phase 3 clinical trial published Wednesday in theJournal of the American Medical Association. 

The vaccine uses the same messenger RNA technology as Moderna’s approved Covid vaccine.(There are no approved mRNA-based flu shots.)

The trial, funded by Moderna, included more than 8,000 adults ages 50 and older who were enrolled in October and November 2023. For people ages 50 to 64, the new vaccine was compared to Moderna’s Covid vaccine and the flu shot Fluarix. For people 65 and older, it was compared to the Covid vaccine and a different flu shot, called Fluzone, which is a stronger dose typically given to older adults. The trial participants either got the existing shots, or the new combination vaccine plus a placebo shot. (This way, both groups got two injections.)

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[–] ddash@lemmy.dbzer0.com 76 points 2 months ago (5 children)

“Immunologically, what’s happening in each cell is they’re acting as if they’ve been infected with both viruses, and so your immune system is going to respond and make the type of inflammation that you would if you had flu or Covid or both simultaneously,” he said.

This will 100% be taken out of context by anti-vaxx crowds.

[–] jonne@infosec.pub 12 points 2 months ago (2 children)

Terrible explanation as well.

[–] Nurse_Robot@lemmy.world 3 points 2 months ago (1 children)

Is it? I understood it. How would you explain it?

[–] jonne@infosec.pub 16 points 2 months ago (1 children)

They use inflammation instead of antibodies for one.

[–] Nurse_Robot@lemmy.world 3 points 2 months ago (1 children)

Antibodies create an inflammatory response, seems like we're really nitpicking here. It's a layman's explanation, not a research study or textbook.

[–] 13igTyme@lemmy.world 3 points 2 months ago

"It does a thing to mimic the bad thing and then the thing gets better so you don't get the real thing."

[–] Ledericas@lemm.ee 3 points 2 months ago

they should call it bivalent vaccine, since its 2 in 1.

[–] Randelung@lemmy.world 6 points 2 months ago

It's nothing new, though. Vaccines have always worked like this - make your body go through the motions without problematic invasive organisms.

[–] JudahBenHur@lemm.ee 4 points 2 months ago (2 children)

honestly so fucking what? let those jokers not get the vaccination. get sick, have permanent symptoms that last your whole life, fuck it, whatever.

in the meantime, my sleeves are pre-rolled up for this shot, put it in my veins doc, I like not basically dying, its kind of a fetish

[–] prole@lemmy.blahaj.zone 12 points 2 months ago (3 children)

I feel like we've had this discussion a billion times since 2019... Do you really still not understand herd immunity?

[–] JudahBenHur@lemm.ee 8 points 2 months ago

Since 2019 I have given up entirely on collective common sense coming from anybody. People are just far too stupid and selfish to get their shit together if it even inconveniences them a tiny bit. I can only do my best to protect myself as relying on people writ large is a fools errand.

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[–] ApexHunter@lemmy.ml 3 points 2 months ago (1 children)

Good luck getting it at all. One of those jokers is head of the HHS and is actively adding obstacles to vaccine approvals.

[–] JudahBenHur@lemm.ee 2 points 2 months ago

I live in Ireland ¯_(ツ)_/¯

[–] 0101100101@programming.dev 2 points 2 months ago* (last edited 2 months ago)

No need to take it out of context. They hear the word "vaccine", smirk at the dumb sheep and shout AUTISM!!!111

[–] jagged_circle@feddit.nl 1 points 2 months ago

Nah those people think covid is the flu and isnt a big deal

[–] uawarebrah@sh.itjust.works 53 points 2 months ago (2 children)

I can’t wait. I love Vaccines. Science is truly amazing.

[–] prole@lemmy.blahaj.zone 11 points 2 months ago (2 children)

I know right? We need more comments like this to counter all the anti-vax bullshit.

I'm not just neutral on vaccines, I think they're fucking amazing and I want more.

[–] jagged_circle@feddit.nl 3 points 2 months ago (3 children)

I don't think we're going to find antivaxxers on Lemmy.

[–] nieceandtows@programming.dev 2 points 2 months ago (1 children)

I'm not antivax but I'm suspicious of these 'subscription' vaccines which don't eradicate the disease but only succeed in helping them mutate every year so that they can keep lining their pockets. Don't we have the scientific advancements to eradicate flu instead of playing a profitable cat and mouse every year? I'm from India, and was very surprised to hear about the annual flu shots when I first came to the US. May be I'm just cynical, and there is just no way to truly eradicate flu accounting for its mutations.

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[–] Ledericas@lemm.ee 1 points 2 months ago* (last edited 2 months ago)

they are all still shilling on reddit, youtube, ,,,etc.

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[–] ours@lemmy.world 9 points 2 months ago

The closest things to miracles we can actually do! Preserving probably millions of lives every year. It used to be normal to have a bunch of kids and just have many of them die or get crippled early in live due to child illness.

Fun fact: in Vietnam, after they kicked out the French, they changed all the French street names with some exceptions. Pasteur was one of those exceptions.

[–] Treczoks@lemmy.world 18 points 2 months ago (2 children)

... unless you are in a country with a crazy antivaxxer at the helm of public health.

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[–] fadingembers@lemmy.blahaj.zone 10 points 2 months ago (1 children)

Does this mean we're still getting a flu shot this year in the US? Last I heard RFK cancelled everything for them

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[–] ieatpwns@lemmy.world 8 points 2 months ago

Not if the brain worms have anything to say about it

[–] eddanja@lemmy.world 3 points 2 months ago

Oh HELL nooo! Not on Worm-Brain's watch!!

[–] fireweed@lemmy.world 2 points 2 months ago* (last edited 2 months ago) (5 children)

Side effects such as fever and chills were more common in people who got the new vaccine.

This caveat, glossed over in the article, is potentially a huge drawback.

Personally, the covid and flu shots by themselves make me feel icky but moderately functional for 24-36 hrs, but the time I had both at once I was practically bedridden for three days.

Obviously not everyone has this problem, but from what I've heard it's common enough that I worry if the two-in-one shot becomes the new standard it will turn a lot of folks off from vaccination altogether. There's enough vaccine hesitancy and skepticism out there already that a miserable reaction (or simply the need to clear your schedule for three whole days) could be enough to cause folks to indefinitely postpone their yearly booster or forgo vaccination altogether.

[–] Ledericas@lemm.ee 3 points 2 months ago (1 children)

only the og first covid made me feverish,achey, plus the pain from the vaccine. that lessened over time as you get more shots.

[–] Akuchimoya@startrek.website 4 points 2 months ago

Everyone reacts differently to different things. I know someone who's side effects were worse each Covid shot he got. He still got them, because he was taking care of an elderly family member, but he had to started planning to be bedridden himself. He's not antivax, but stopped getting boosters when the family member died because he didn't want to be laid up for a week at a time.

[–] RememberTheApollo_@lemmy.world 2 points 2 months ago

I find the Moderna vaccine in general (covid only) makes me feel worse than the Pfizer one. No idea why, but making it worse won’t prevent me from getting vaccinated, I’ll just get separate vaccines.

As long as people have choices, and they know what they are, it shouldn’t be a big deal. The problem will arise when people don’t know/have a choice and feel like crap when given the combo vax.

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