The first time I boot up the game, immediately show me the settings menu. Whether its window settings, sound volume, subtitles, or graphics settings, please do not make me sit through a long cutscene or (god forbid) make me play the game without being able to adjust settings first. Sometimes the window is screwed up, the graphics are pushing my system too hard, or any number of other issues on first boot.

I can think of 1 or 2 games that booted to settings or booted to a truncated settings menu with common settings, but I would love if this became standard for all PC games.

Save&quit at any time

So I can just boot up the game, play for 15 minutes and go do other stuff

Pause and save during cutscenes.

If your game supports controller give me the option to change the button faces to whatever I prefer. Some people like Nintendo button layout, others PlayStation, other Xbox. Whatever it is, don't hard code one set - they're just some pngs, support them all.

Every game should have the option to toggle motion blur off, toggle frame gen and upscaling off.

Windowed borderless mode

Subtitles. I wish I could have suuttiles for halo, the early games. It's getting better these days, and should be a setting accessible before starting the game (not after the intro movie, I'm looking at you vanilla wow).

I also think ANY game should have a “full potato” mode capable of running in older computers with NONE of the fancy graphics stuff that we have access to today, despite having a decent computer now.

Problem is that the fancy graphics stuff isn't just additive.
For example, raytracing is actually relatively simple to implement, since you just make light behave like it does in real-world physics, according to a couple relatively straightforward rules and material properties.
Lighting without raytracing involves tons of ~~smokes and mirrors~~ hacks and workarounds. For example, mirrors were often faked by building the same room behind the wall, with everything inverted, including the player character's animations.
So, making a game with potato graphics typically requires building a second version of the game.

Of course, there can be a mode that does just turn off the additive stuff, so only that which does not require changing the game implementation. But that can just be one of the graphics presets...

You just reminded me of a funny feature I found in Elite Dangerous (space MMO) to prevent combat logging (quitting suddenly during combat like a little b***h): if you press Alt+F4, the game doesn't immediately exit, but shows you a Quit dialog (to main menu or desktop), and there's a lengthy countdown if you're near hostile ships. :)

Doesn't prevent it entirely, but I thought it was pretty crafty.

Colorblind options that let me specifically choose the color of each HUD/UI element. I don't want an overlay for the whole game, I just want to be able to distinguish icons in the UI that might have color-coding too similar for my eyes to perceive at a glance

Ohh, that type of setting.

One option I really appreciated in Uncharted 4 was the ability to restart cutscenes, and I wish it was in every game with cutscenes.

I'm not sure about every game but I'd like to see a lot more games do what Rebel Galaxy did and let you set up paths for custom OST. No game dev can license the perfect soundtrack for every player, but it's great to be able to slot in what I feel makes the perfect soundtrack. Some people want their fight scenes to be scored with DMX, some want Burzum, and some want the Cronos Quartet. Let them all find their moment.

Let me choose my own resolution.